This does NOT mean Python will get Tail Call Optimization, as Guido cannot be shown The Light, and has decided.
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Looking at python from the outside a lot of changes since GvR stepped down seem like stuff he'd not have been fond of.
Moreover, Guido is in favour of ongoing addition of major new features (like pattern matching), worrying that without them Python would become a “legacy language”:
https://discuss.python.org/t/pep-8012-frequently-asked-quest...
I don't follow python closely so it may 100% be stuff that GvR endorsed too, or I'm mixing up the timelines. It just feels to me that python is changing much faster than it did in the 2.x days.