Starship Flight 7

Yes, very much looks like it.

I wonder how much of the second stage flight is autonomous and if they need to continually need to give it a go to continue, or if it aborts automatically after some time of lost telemetry. But maybe it already exploded anyways.

Probably self destructs if anything goes wrong

If it has control issues or similar absolutely, but does losing comms count as going wrong for the FTS? If the flight itself is on track?

The flight control loops are strongly latched. They are constantly checking the state of discretes, control surfaces, and intended guidance. If any critical parameter gets out of range for a period of time or if any group of standard parameters gets out of range the vehicle will simply cease powered flight.

In the Space Shuttle, given that it was human rated, the "Range Safety" system was completely manual. It was controlled by a pair of individuals and they manually made the call to send the ARM/FIRE sequence to the range safety detonators.

Absolutely. All those contingencies are planned out and coded down in software.

The automated FTS is triggered if it leaves a pre-defined corridor (which is wider than the flight plan - substantially so in some places).

The AFTS has independent, hardened, validated inertial measurement systems.