I would also say absolutely. We've been using pipenv for ~6 years and have managed to build a pretty good workflow around it. But uv is just _so much faster_. So we've started moving everything over to uv and I don't think we'll ever look back.
Migrating is not super hard, we wrote a small script that moves all the information from a Pipfile to a pyproject.toml and it works like a charm.