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GMoromisato ◴[] No.42186404[source]
I'm conflicted about all of this because I gave up reading Scientific American when I felt it had become too political.

But of course, you can't remove politics from science. Scientists are human and humans are political. When a scientist chooses an area to investigate, it is influenced by their politics. You can ask scientists to be factual, but you can't ask them to be non-political.

It's not SciAm's fault that scientists (and science writers) are political.

The root failure, IMHO, is that several professions, including scientists, journalists, and teachers have become overwhelmingly left-wing. It was not always that way. In the 80s, 35% of university employees (administrators+faculty) donated to Republicans. In recent years it has been under 5%.[1]

I don't know the cause of this. Perhaps conservatives began rejecting science and driving scientists away; or perhaps universities became more liberal and conservative scientists left to join industry. Maybe both.

Personally, I think it is important that this change. Science is the foundation of all our accomplishments, as a country and as a species. My hot take is that trust in science will not be restored until there are more conservative scientists.

Sadly, I think restoring trust will take a long time. Maybe this change at Scientific American will be the beginning of that process. I certainly hope so.

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[1] https://www.nature.com/articles/s41599-022-01382-3.pdf

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disentanglement ◴[] No.42186511[source]
Or perhaps the republican party has developed such an astonishing anti-science attitude that hardly any reasonable scientist can support them? Imagine doing research on vaccines and hearing the soon to be secretary of health speak on that topic. As long as these kind of people count as "conservatives" in the US, how could you be a conservative scientist?
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TimTheTinker ◴[] No.42187046[source]
> Imagine doing research on vaccines and hearing the soon to be secretary of health speak on that topic.

I hope I'm not entering a minefield here... but from what I've heard, it sounds like he's not against vaccines in principle, just ones that haven't undergone clinical trials equivalent to what the FDA requires for pharmaceuticals.

(A sound byte I heard sums it up, where he said something like "no one called me anti-fish for working to get mercury removed from the fish sold in supermarkets, so I don't see why I should be labeled 'anti-vaccine' either.")

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cromwellian ◴[] No.42187287[source]
No, he’s pretty much against them and makes a new excuse each time. He would claim that no vaccine ever has gone through enough testing.

He also denied HIV causes AIDS, days it’s Poppers or lifestyle.

He also pushed ivermectin which studies show has no statistically significant effect on COVID.

He also pushed raw milk when prior to pasteurization, milk was the cause of 25% of all communicable diseases (it’s a great medium for bacteria, it has avian flu viruses, parasites, etc). We invented pasteurization for a reason.

The guy latches on to whatever statistical outlier study he can find like an ambulance chasing lawyer and is a threat to public health that has been massively improved over the last century.

All of his attacks on dyes and seed oils won’t move the needle when the real reason for US health decline is too much sugars/carbs, too little exercise, and addiction to opioids and nicotine.

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roenxi ◴[] No.42187751[source]
> He also pushed ivermectin which studies show has no statistically significant effect on COVID.

Studies showed that it had a statistically significant effect on COVID. The problem is that with hindsight it is obvious any sufficiently powerful study will show it has a statistically significant effect so the existence of that effect isn't particularly interesting evidence.

There will be people who have both COVID and parasites. If you give them Ivermectin around the time they catch COVID, they will get better outcomes. Statistics will pick that up, it is a real effect. AND it has real world policy implications, there are a lot of people in the world who should immediately be given Ivermectin if they catch COVID (or, indeed, any disease). The more important political issue was when people noticed that (very real) effect without understanding the cause they were attacked rather than someone explaining what was happening.

It is a good case study of evidence being misleading, but the statistical significance of that evidence is indisputable. Any study that doesn't find that effect is just underpowered - it is there. In fact as a baseline it turns out we would expect any effective drug will have a statistically significant positive effect on COVID outcomes.

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1. cogman10 ◴[] No.42188380[source]
> Studies showed that it had a statistically significant effect on COVID. The problem is that with hindsight it is obvious any sufficiently powerful study will show it has a statistically significant effect so the existence of that effect isn't particularly interesting evidence.

Preliminary studies with small n showed a statistically significant effect. Follow up studies with larger n showed no such effect. Meta studies also concluded no effect.

> Any study that doesn't find that effect is just underpowered

I'm sorry, but no, in fact the opposite is true. The underpowered studies are the only ones showing an effect. [1].

What has happened with Ivermectin is the "anchoring effect". [2] Early studies showed promise which has caused people to think there is promise there. After that, grifters and conspiracy peddlers started out publishing the actual research on the benefits.

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC9308124/

[2] https://en.wikipedia.org/wiki/Anchoring_effect

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2. roenxi ◴[] No.42189139[source]
If you believe that, it implies you believe someone infested with parasites expects the same COVID outcomes as someone who is mostly healthy. That is a pretty extreme claim, to the point where 1 study (or review, in this case) isn't really an argument. It is much more likely that that they just aren't picking up the statistical signal that is obviously going to be there somewhere.

There isn't a shortage of studies showing an ivermectin-COVID relationship. https://c19ivm.org/meta.html makes for interesting reading, although it is quite misleading because it is probably measuring parasite prevalence rather than anything new.

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3. cogman10 ◴[] No.42189440[source]
> If you believe that, it implies you believe someone infested with parasites expects the same COVID outcomes as someone who is mostly healthy.

No, it doesn't.

The crux of your argument is that there is an invisible parasitic pandemic which is, frankly, absurd. Parasites by their nature are far less transmissible than an airborn virus is. They are primarily regionally locked and locked out of most developed countries. The US, for example, does not have a major internal parasite problem because public waters are treated against most parasites and filtered before general consumption.

As for the site, it's got a lot of pretty numbers that are like "Yeah look, 100% this ivermectin is great!" which is pretty fishy. You would not expect to see something like that. But, scroll to the bottom and all the sudden you see why that is, they purposefully find reasons to omit all studies that counter that claim.

Like, I'm sorry, I'm just not going to trust a website that is pushing for vitamin D supplements to treat covid. It's not a serious website and it has a very clear agenda.

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4. defrost ◴[] No.42189511{3}[source]
Yourself (cogman10) and roenxi might both be in furious agreement from my PoV.

There are no good studies showing a useful relationship between ivermectin and COVID outcomes in low parasite G20 countries ( UK, AU, US, etc ).

The early studies most quoted had high N, good procedures, and showed ivermectin having a very positive effect across the board wrt many diseases ( flu, COVID, etc. ). These studies were in countries and regions with high parasite prevelance and demonstrated pretty conclusively that people with no worms were healthier, had better functioning immune systems, and both resisted and recovered from infections noticably better than untreated populations with parasites.

The supplement pushing website is being disingenous and obfuscating the context of the studies quoted in order to flog crap to rubes.

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5. roenxi ◴[] No.42189588{3}[source]
> No, it doesn't.

Alright, lets go through this slowly. Run me through the point which you think is unreasonable:

1. We do a study. Some % of the participants have parasites, in line with the base rate for the area.

2. Split the group into experiment and control. The experiment group gets Ivermectin.

3. Wait until everyone gets COVID. The people with parasites in the control group get terrible outcomes because their immune system is way overloaded, but the people who used to have parasites in the Ivermectin group do a bit better because they just took an anti-parasitic.

4. A sufficiently powerful statistical analysis correctly detects that the two groups got different COVID outcomes.

What part of that do you think won't happen in the real world?

6. boredtofears ◴[] No.42190743{4}[source]
Best thing I've read that's summarized this well is the Scott Alexander piece incase anyone wants to do further reading from a somewhat reputable source: https://www.astralcodexten.com/p/ivermectin-much-more-than-y...
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7. defrost ◴[] No.42190832{5}[source]
Fun read; I knew of the "good studies" that Scott ended up with, I'd never bothered to look much at the site in question as it screamed (to myself at least) of marketing driven bias .. and lo and behold many of the quoted papers are low N, sketchy, or outright fraudulent.

I suspect the best most concise summary is simply "If you have or even suspect you have worms, take ivermectin. Your general health and well being will most probably improve".