Sure. But PyPI provides zero details on the process, I don't use 2FA for anything else in my life, no one is paying me to care, I find making PyPI releases tedious because I inevitably make mistakes in my release process, I have a strong aversion to centralization and dependencies[1][2].
I tell people to "pip install -i $MY_SITE $MY_PACKAGE". I can tell from my download logs that this is open to dependency confusion attacks as I can see all the 404s from attempts to, for example, install NumPy from my server. To be clear, the switch to 2FA was only the triggering straw - I was already migrating my packages off of PyPI.
Finally, I sell a source license for a commercial product (which is not the one which got me started with PyPI). My customers install it via their internally-hosted PyPI mirrors.
I provide a binary package with a license manager for evaluation purposes, and as a marketing promotion. As such, I really want them to come to my web site, see the documentation and licensing options, and contact me. I think making it easier to express as a dependency via PyPI does not help my sales, and actually believe the extra intermediation likely hinders my sales.
[1] I dislike dependencies so much that I figured out how to make a PEP 517 compatible version that doesn't need to contact PyPI simply to install a local package. Clearly I will not become a Rust developer.
[2] PyPI support depends on GitHub issues. I regard Microsoft as a deeply immoral company, and a threat to personal and national data sovereignty, which means I will not sign up for a GitHub account. When MS provides IT support for the upcoming forced mass deportations, I will have already walked away from Omelas.