we more or less do for all the applications in my team, which don't follow the corporate standard.
They're all Django applications, and the limited dynamic elements are just simple jquery. We have some bootstrap stuff and elements like form elements in javascript, but that's about it.
We are extremely productive, especially compared to our official apps which follow the .NET/Angular stack, that run into all kinds of API versioning issues and errors, it's not even a faster user experience. The problem with such a stack is that you need a few highly skilled architects/system designers. We just have regular programmers piecing it all together, most of them learned these frameworks on the job and come from a regular app dev background, not web.
Granted, we only serve something like 20-30 concurrent users for each of tthe Django apps (as in, page requests/second), but still...