I got laid off thrice during my 25+ year career during which i have worked at 9 different companies. twice from startups in each of the previous busts and once from a large company. job hunts are not easy and i dont interview well.
however, there are tech transitions and it appears we are in the midst of one - after which a new set of tech careers seem to emerge. internet/web/mobile/cloud/saas and whatnot. i fully expect the same to happen here.
so, hang in there, and keep your sword sharp.