When RTO becomes mandatory, working from home also necessarily becomes more difficult in its own right. The lower the percentage of employee hours worked at home, the worse the company is at working with employees who work from home, regardless of their reason.
Not only is applying for an exemption getting harder, being successful even once you have it is going to become darn near impossible.
I think it's safe to say Amazon is openly creating a work environment hostile to people who have disabilities that prevent them from working in an office. If you're one of those, make your plans to get out, and go somewhere that realizes they're lucky to have you. This is only going to get worse, not better.