Tangential topic: I see some suggestions for NextDNS here as an additional layer. I can’t speak for Android, but if you’re looking for iOS/iPadOS/macOS/tvOS, note that NextDNS does not work well on these. The app hasn’t been updated for several years and toggling on the app does nothing (I like the app because I can quickly switch it off and on when needed, which cannot be done with a profile). Most of the time the test page at test.nextdns.io shows as “unconfigured”. Even the profile installation approach does not work on Apple TV (I’ve tried this a few times). Overall, the NextDNS servers around the world exist, but there is zero support and maintenance on the client side for the platforms I mentioned. The community forum has posts about issues that the founders don’t respond to.
At least on macOS, I have Little Snitch that acts as a system wide blocker (one can subscribe to blocking lists just like in uBlock Origin).