A group of coworker friends and I used to find the most creative ways to mess with each others' computers if they were left unattended. Some of the ones I can remember off the top of my head:
1. A Chrome extension that slowly rotated every <div> on the page (think 1 degree every 10 minutes). Would be hard to notice unless a page had been left open for a while. 2. Another Chrome extension that would redirect to a full-screen gif of John Cena that would only load after a random number of page loads. 3. A horn sound that would play after every successful git commit, regardless of computer volume. 4. A Slack bot that would scrape another coworker's insufferable Reddit comments, store them in a database, and then use ML to interject the comments into our conversations based on some basic NLP. This one was my favorite.