https://www.picardlab.org/uploads/7/7/8/4/77845210/2022_bobb...
Lots of interesting stuff about mitochondrial allostatic load. It's essentially a Goldilocks problem - the car that's never driven breaks down quickly when you take it out for a drive, but if you're constantly pushing the accelerator and slamming the brakes, the car's lifetime is cut in half. The paper seems to focus on social and psychological factors that unnecessarily increase stress:
> "From this energetic perspective, the evolution of likes and dislikes, feelings and emotions, and approach/withdrawal behaviors arose to minimize the energetic cost of life."
Case example: Someone just asked me about my holiday season plans and my blood pressure probably went through the roof... I think I'm going to send them this paper.