I wonder how Ozempic will change this? I really do expect we will all be on this soon and maybe we can resume the increase in lifespan that has been stalled by obesity, lack of exercise, and processed food.
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When antibiotics were first invented some people thought we'd be taking them daily as a vitamin. Turns out that's not such a good idea despite them being life saving in some scenarios
And there are potential bad side effects too.
It has a side effect of reducing muscle gains from exercise.
As for life extension by GLP-1 active drugs, it's much more of a guess. Mechanism is relatively similar. Side effects might not be...
If a doctor tried to push that on me I would fire that doctor.
Life expectancy is a weighted average (no pun intended), and so it's unusually sensitive to outliers. People who die early drag the average down much more than people who live close to the mean life expectancy. The biggest premature killers of Americans are obesity, drugs, car accidents, and suicide. Anything that addresses one of those causes of death has an outsize effect on life expectancy. There are 100M+ obese Americans. There are about 100,000 overdose deaths per year. Obesity, while not as lethal as drugs or suicide, afflicts 1000x as many patients, and so a treatment for it can have a large effect on the numbers.
Sure, if all the weights are 1. Where i come from, we just call that an average.
>People who die early drag the average down much more than people who live close to the mean life expectancy.
This is true of all averages where all weights are the same.
https://www.ox.ac.uk/news/2009-03-18-moderate-obesity-takes-...
> According to the CDC, 9.4% of adults in the United States were severely obese between August 2021 and August 2023. This is higher for women (12.1%) than men (6.7%). The prevalence of severe obesity varies by age group, with the highest rates in adults aged 40–59 (12.0%)
Only 9.4% of people are severely obese. Moderately obese people have only a ~4% shorter life-span than healthy weight individuals - much of which can probably be attributed to other lifestyle issues besides simply being overweight.
This will move the needle, but I doubt as much as you think.
There's a lot more smokers than there are severely obese people.
(To reproduce exactly the scenario being discussed, you fit a constant-only model to the data using least squares: that gives the average as the best fit. Then, you measure the leverage of each point of interest.)
Which, I recognize is a pretty privileged way of putting it—people struggle with weight, mental health, and drugs, and those are real struggles that shouldn’t be ignored. I just also want to see where things are developing on the upper-bound for reasonably plausible lifespans.
Huh, I was going to argue this, but you're right (in the US). 19.5% of the population smokes, so there's about twice as many smokers as severely obese people.
I was sure it had dropped to 5-10%. I guess I'm in a bubble (of fresh air).
https://www.wired.com/story/the-benefits-of-ozempic-are-mult...
> Known as GLP-1 agonists, these drugs were originally developed to help control diabetes. But there's increasing evidence that they have other health benefits, beyond controlling weight. They seem to boost heart health, protect the kidneys, improve sleep apnea, and lower the risk of certain obesity-related cancers.
We’re really flying in the dark there.
I guess we’ll soon be able to measure the impacts on what it does to the children of parents that take it.
How have McDonalds Happy Meal sales been looking lately?
Since everyone knows smoking is bad for a long time now, we’re going to eventually need to categorize stuff like lung-cancer as a death of despair, similar to other deaths caused by alcoholism, opioids, or suicide.
A lot of people who otherwise might quit smoking are probably looking at impossible dreams of home ownership or retirement, and thinking consciously or unconsciously that there is more dignity in a death at 50-60ish than one at 80ish when you’re unemployable and the thin promises of social safety nets have fallen through.
Smoking (or other high risk activities) might be a dirty habit but it’s still more socially acceptable than suicide.
Most of them are smoking primarily because they're addicted.
A few of them actually like smoking.
The accepted view is a lot like the accepted views to mono-cultures for crops. In that they are bad. The practiced take, though, is quite the opposite? Crops are dominated by mono-cultured fields. And though antibiotics are known not to be used constantly, farms seem to use them at an amazing rate.
I'd love to see a longer exploration of this. Why is it farms seem to be full of practices that we are taught are bad?
If obesity is supposed to be the other main candidate for why life expectancy is down, you can do a similar analysis there. Is life really good enough to prolong or attempt to improve for people that are in at-risk categories? That’s the question people are looking at when they choose to move towards or away from self-care. For someone who makes minimum wage and already has to choose between paying for a date or paying for rent, it makes less sense for them to care much about losing weight, because it makes a bad life longer but won’t help their love life.
This is how practically all population-level analysis of health is just economics in disguise, even without directly looking at costs of medicine/services
At any rate, I'll be reading more on this some. I have real work I should be doing, after all. :D