Any ideas on how you would run SSL/TLS on these set-ups?
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The automated setup probably isn't very secure, though. Anyone can register any .local name on the network, so spoofing hostnames becomes very easy once you get access to any device on the network. Send a fax with a bad JPEG and suddenly your office printer becomes xvilo.local, and the ACME server has no way to determine that it's not.
That means you probably need to deal with manual certificate generation, manually renewing your certificates every two years (and, if you're like me, forgetting to before they expire).