I got almost all of my wishes granted with RP2350

Some specs here: https://www.digikey.ca/en/product-highlight/r/raspberry-pi/r...

Based on the RP2350, designed by Raspberry Pi in the United Kingdom

Dual Arm M33s at 150 MHz with FPU

520 KiB of SRAM

Robust security features (signed boot, OTP, SHA-256, TRNG, glitch detectors and Arm TrustZone for Cortex®-M)

Optional, dual RISC-V Hazard3 CPUs at 150 MHz

Low-power operation

PIO v2 with 3 × programmable I/O co-processors (12 × programmable I/O state machines) for custom peripheral support

Support for PSRAM, faster off-chip XIP QSPI Flash interface

4 MB on-board QSPI Flash storage

5 V tolerant GPIOs

Open source C/C++ SDK, MicroPython support

Software-compatible with Pico 1/RP2040

Drag-and-drop programming using mass storage over USB

Castellated module allows soldering directly to carrier boards

Footprint- and pin-compatible with Pico 1 (21 mm × 51 mm form factor)

26 multifunction GPIO pins, including three analog inputs

Operating temperature: -20°C to +85°C

Supported input voltage: 1.8 VDC to 5.5 VDC

Edit: See comment below; The RP2350 can be powered by a 5V supply.

To clarify: You can connect a 5V power source by connecting it to the VSYS pin which leads into the on-board voltage regulator.

But the µC itself runs on 3.3V and is not totally 5V-capable. You'd need level converters to interface with 5V.

You're right, after re-reading the Power section on the datasheet it seems connecting 5V to the VREG_VIN should suffice to power the digital domains, but if you want to use the ADC, you still need a external 3.3V source.