Or, as Dr Malcom would say: life, uh, finds a way.
This should be a crucial piece of information about the tree laws, yet it's not mentioned in the Wikipedia article about the three laws [1], which is otherwise quite detailed. Reading this, everything makes me think that it was not a parody. I didn't feel like it was parody when reading the Robot series neither. He wanted an alternative to the Frankenstein plot where robots kill their creators and the three laws were part of the answer.
I think the strongest evidence is that many other examples of Asimov, especially short stories are cautionary and deal with hubris and unexpected side effects.
However it's funny to ask for 'evidence' about fiction in the context of "parodying rationalists". no? Since what would count as evidence? Another, more "authoritative" literary interpreter saying the same thing? Maybe a long time ago - historical statements seem to carry more weight, as if people were wiser back then?. Or Asimov himself? But don't they say, only bad writers explain themselves?
Asimov writing about his intent
> But don't they say, only bad writers explain themselves?
...No? If someone says that, why do you believe them? That frankly sounds like a pretty stupid and lazy claim about the world. One of the most interesting parts of, for example, Tolkien analysis is his abundant notes and letters working out his intent and meaning.