One major effect of this is that weed stores will be able to use banks and payment processors legally once the regulators catch up.
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Here in Ontario Canada I can walk into a local neighbourhood cannabis store (one of many on every block, it seems) and make a purchase using my debit or credit card. I'm not sure if any of them even keep a cash float although I imagine they must, just in case granny comes in "for medicinal use". Alternatively, I could just go to the government-run web store and get home delivery through Canada Post at no extra charge.