One major effect of this is that weed stores will be able to use banks and payment processors legally once the regulators catch up.
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They have cash-handling processes similar to a casino, but again, they have much less than a casino or bank to take.
Employee theft is a much bigger problem than robbery, because you can imagine who works at them, but even then, it's hard to get away with.
You'd be much better off robbing a busy gas station or the like.