We moved entire infrastructure to AWS last year, to speed up/simplify/rethink it. We lasted 3 months on S3/CloudFront. We are still heavily invested in AWS, but moved our production storage/distribution to R2/Cloudflare and couldn't be happier.
Next up: moving our cloud edge (NAT Gateways, WAF, etc) to Fortinet appliances, which licenses we purchased bundled with our on-prem infra.
I know Corey Quinn always harps on AWS' egress pricing but you really can't emphasize it enough: it's literally extortionary!