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A New Mode of Cancer Treatment

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322 points atomroflbomber | 1 comments | 03 Aug 23 08:12 UTC | HN request time: 0s | source
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flobosg ◴[03 Aug 23 09:56 UTC] No.36983634[source]▶
Not a medical chemist, but I noticed that three AOH1996 molecules are binding to PCNA. Would it make sense to chain together three AOH1996 molecules with flexible linkers for, I don't know, increased specificity or something like that?
replies(1): >>36983803 #
irdc ◴[03 Aug 23 10:21 UTC] No.36983803[source]▶
Maybe. But a bigger molecule will be less soluble and less capable of getting into the cell.
replies(1): >>36984202 #
flobosg ◴[03 Aug 23 11:18 UTC] No.36984202[source]▶
Right! I forgot about good ol’ Lipinski: https://en.wikipedia.org/wiki/Lipinski%27s_rule_of_five
replies(2): >>36984970 #>>36986934 #
1. dekhn ◴[03 Aug 23 15:05 UTC] No.36986934{3}[source]▶
it's more like guidelines than a rule.