Program isolation is honestly a feature that other distros should use more often. The idea that programs can only access networks, USB devices, files, and X windows of programs that it's been explicitly let to access is an extremely useful tool that isn't just for people who are worried about government surveillance.
I personally enjoyed having about 5 different Firefox apps that each led to their own VM with its own files, browser history, cookies, and extensions, and even networks that automatically put traffic through a VPN at times. Chrooting and Firefox profiles only help so much, if you can even set them up to be as seamless as Qubes.
I'm of course not getting into the security benefits and all that of Qubes, but its where I feel a lot of people don't realize the benefits of an OS like this. The workflow improvement is just as inspiring as the security improvement from the system.