I really like QubesOS, but you cannot run VMs inside a qube, or other things that require VMs like Docker Desktop for Linux, because the xen hypervisor does not support nested virtualization.
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Nested virtualization is a game changer in any kind of lab scenario. It also runs great on Chromebooks. The ChromeOS Linux environment is actually a KVM, so launching virtual machines from there is nested but you would never know it (based on my experience with the (framework Chromebook edition). Having 64GB of memory doesn't hurt either of course.