0. implicit reliance on a network internet connection means any loss of ACME to the letsencrypt CA makes renewal of the cert or OCSP problematic. if the internet goes down, so does much of the intranet nonreliant upon it.
1. wildcard certs make setting up an attack on the network easier. you no longer need an issued cert for your malicious service, you just need to find a way to get/use the wildcard. you should know your services and SANs for the certs. these should be periodically audited.