I have used Noweb a few years ago [^1] for a small Python program; there were two major issues with it, from my PoV:
- I had to take care of writing each Python code chunk with the amount of indentation appropriate for where it had to end up, since Noweb does (did?) not respect relative indentation of chunks when tangling.
- Debugging the resulting script was more painful than plain Python sources, as all the debugging info (line numbers, etc.) referred to the tangled code and not to the actual noweb source file I was editing.
[^1]: Looking at the website, it doesn't seem to have changed much since then.