I'd like to add to discussion [1] which shows relation between stress and autoimmune disease, [2] (Russian) case study of a Russian businessman who burned out (lost a part of cortex due to autoimmunte disease) and [3] encephalitis provoked by emotional stress.
[1] https://www.health.harvard.edu/blog/autoimmune-disease-and-s...
[2] https://www.forbes.ru/karera-i-svoy-biznes/392253-kukushechk...
[3] https://www.shmabstracts.com/abstract/stress-is-the-enemy-a-...
And he was clearly overworked, by my guess.
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