Which is why it's good to have a mature VM underneath your language. Paul's choice of basing an implementation of Arc on MzScheme was a very good one (I remember people criticizing him for not building a standalone implementation with a new VM).
I write time-critical applications in Clojure and JVM's -XX:+UseConcMarkSweepGC flag is a lifesaver. We no longer get those multi-second pauses when full GC occurs.
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