The closest you can get to Qubes on Windows would be to follow Microsoft's Privileged Access Workstation (PAW) guide, but it requires a lot of additional infrastructure[3]. That infrastructure allows you to do remote attestation of the virtual machines, but makes it costly to deploy in a SMB or homelab environment.
I don't expect it'll be very long before PAW and WDAG are usable at the same time, with colored window borders indicating the origin virtual machine. I hope this is on Microsoft's roadmap.
Video on privileged access workstation use, starting at a demo: https://youtu.be/3v8yQz2GWZw?t=41m48s
Video on privileged access workstation setup: https://www.youtube.com/watch?v=aPhfRTLXk_k
[1] https://docs.microsoft.com/en-us/windows/threat-protection/w...
[2] https://clearlinux.org/features/intel®-clear-containers
[3] https://docs.microsoft.com/en-us/windows-server/identity/sec...