The biggest problem is the lack of a certified laptop. Librem13 was certified for R3 but as of now there is nothing certified for R4 [0]. Their stance on Intel ME is clear and good. I hope they don't give it up or water it down with commercial licensing. So theoretically if I approach them as a company and tell them I want to get Qubes on company laptops they should tell me no laptops are secure.
One of the most interesting OS project imo, I hope there will be some changes on the hardware side eventually but unfortunately I remain skeptical.
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