I critiqued QubesOS in the past over re-inventing the wheel and on a highly insecure platform. Her recent write-up supports my critique more than ever. Regardless, they're at least doing something with provable benefit and high usability on a platform with proven benefit, both of which can be further secured or extended by others. An exception to the rule of mainstream INFOSEC where the sense of security is almost entirely false as no effort is taken to address TCB.
The only project in this space leveraging best practices in TCB or architecture is GenodeOS. They're doing what I suggested QubesOS do a while back: build on all proven, low-TCB techniques in academia. Main critique I had of them is they're too flexible and need to focus on a single stack long enough to get it working solidly like Qubes team did. They stay building on and integrating the better stuff out of L4 family of security engineering research, though.