IMO what CSS layout really needs is:
1. A "proportion of available space" unit. That is, something like the fr unit in CSS grid except applicable to the width/height properties so it can be used in all layout modes and without an implying content-based minimum size (like fr does).
2. A new "display: stack" (name provisional) layout mode that simply stacks boxes one after the other like "display: block" but that works in both axes, and doesn't have quirks of block layout (margin-collapsing, floats, inline-block splitting, etc).
When combining 1 and 2 you'd have a much more intutive layout system that would still give you most of the power of Flexbox and could be implemented with much better performance.
(and you'd still be able to use the existing layout modes if/when you needed to extra power)