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599 points gmays | 1 comments | | HN request time: 0.208s | source
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gcanyon ◴[] No.45775566[source]
What I want to know is: can we trigger these flushes? My grandfather died of/with Alzheimer’s, and I’d prefer not to follow in his footsteps. If we determine that these flushes are key to good brain health, and there were a way either through a pill or even a treatment to up the frequency of these flushes, that would be awesome.
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pedalpete ◴[] No.45776557[source]
We can't "trigger" the flushes, however, it looks like we can increase the power of the pump.

This is specifically the area we work in traditionally called slow-wave enhancement which is stimulating the restorative function of sleep.

This paper [1] specifically looks at amyloid response as a result of stimulation and shows a corresponding relationship between stimulation response, amyloid response, and memory. I wouldn't say it's putting a bow on the results, but it is a very promising result.

If you're curious about what we're building, I'll be posting a ShowHN next week which dives into some of the data in a way regulatory requirements don't permit us to do on our website, but until then, check out https://affectablesleep.com

[1] https://doi.org/10.1093/ageing/afad228

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amluto ◴[] No.45778471[source]
Why is a headband a subscription service?
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pedalpete ◴[] No.45780040[source]
The only way to make this a viable business. We experimented with full price up front, and didn't get any sales.

Long-term particularly if we can make the numbers work for a monthly subscription, it makes the technology more accessible.

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amluto ◴[] No.45783228[source]
I feel like sleep technology may be close to the worst market for this sort of tethered technology. I do not want a gizmo on me that is connected to the Internet when I’m sleeping
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1. pedalpete ◴[] No.45785180[source]
Our headband does not require an internet connection or bluetooth while sleeping. Data can be uploaded in the morning.