There’s about a factor of 3 improvement that can be made to most code after the profiler has given up. That probably means there are better profilers than could be written, but in 20 years of having them I’ve only seen 2 that tried. Sadly I think flame graphs made profiling more accessible to the unmotivated but didn’t actually improve overall results.
If you see a database query that takes 1 hour to run, and only touches a few gb of data, you should be thinking "Well nvme bandwidth is multiple gigabytes per second, why can't it run in 1 second or less?"
The idea that anyone would accept a request to a website taking longer than 30ms, (the time it takes for a game to render it's entire world including both the CPU and GPU parts at 60fps) is insane, and nobody should really accept it, but we commonly do.
I always liked Shaw’s “The reasonable man adapts himself to the world: the unreasonable one persists in trying to adapt the world to himself. Therefore all progress depends on the unreasonable man.”