There’s about a factor of 3 improvement that can be made to most code after the profiler has given up. That probably means there are better profilers than could be written, but in 20 years of having them I’ve only seen 2 that tried. Sadly I think flame graphs made profiling more accessible to the unmotivated but didn’t actually improve overall results.
The common element between attempts is new visualizations. And like drawing a projection of an object in a mechanical engineering drawing, there is no one projection that contains the entire description of the problem. You need to present several and let brain synthesize the data missing in each individual projection into an accurate model.
The sandwich view hides invocation count, which is one of the biggest things you need to look at for that remaining 3x.
Also you need to think about budgets. Which is something game designers do and the rest of us ignore. Do I want 10% of overall processing time to be spent accessing reloadable config? Reporting stats? If the answer is no then we need to look at that, even if data retrieval is currently 40% of overall response time and we are trying to get from 2 seconds to 200 ms.
That means config and stats have a budget of 20ms each and you will never hit 200ms if someone doesn’t look at them. So you can pretend like they don’t exist until you get all the other tent poles chopped and then surprise pikachu face when you’ve already painted them into a corner with your other changes.
When we have a lot of shit that all needs to get done, you want to get to transparency, look at the pile and figure out how to do it all effectively. Combine errands and spread the stressful bits out over time. None of the tools and none of the literature supports this exercise, and in fact most of the literature is actively hostile to this exercise. Which is why you should read a certain level of reproval or even contempt in my writing about optimization. It’s very much intended.
Most advice on writing fast code has not materially changed for a time period where the number of calculations we do has increased by 5 orders of magnitude. In every other domain, we re-evaluate our solutions at each order of magnitude. We have marched past ignorant and into insane at this point. We are broken and we have been broken for twenty years.