Exogenous ketones (such as BHB salts) are known to help with glymphatic drainage in the brain during sleep. I've used them extensively and have noticed improved sleep with nearly a doubling of the time spent in REM stage.
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Here is some literature that I've perused to support my experimentation with BHB salts:
1. β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain (https://www.sciencedirect.com/science/article/pii/S245194562...)
2. Refueling the post COVID-19 brain: potential role of ketogenic medium chain triglyceride supplementation: an hypothesis (https://www.frontiersin.org/journals/nutrition/articles/10.3...)
My motivation for pursuing this was protracted sleep disturbance from long-covid.