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589 points gmays | 2 comments | | HN request time: 0.468s | source
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cyberdrunk2 ◴[] No.45772428[source]
I wonder if this could help explain why creatine helps mitigate the effects of sleep deprivation. Since creatine aids in water retention.

https://pubmed.ncbi.nlm.nih.gov/16416332/

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layer8 ◴[] No.45772453[source]
It’s not clear how water retention would help with the needed flushing.
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1. regularfry ◴[] No.45772495[source]
Hypothetically, more water retention would mean that the fluid being flushed is less concentrated, and if the flushing mechanism is triggered by a certain concentration level then it'll happen less frequently.

Hard to imagine that it would be worth more than a few percent though.

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2. layer8 ◴[] No.45772533[source]
Less flushing sounds like it would also worsen the sleep deprivation, even if it reduces the momentary lapses.